2016 Mercedes-Benz E350

3.5L 6-cyl · 7-speed automatic · RWD

GasolinePremiumMidsize Cars

Official EPA record #36180 from FuelEconomy.gov · data 2026-07-26 · every assumption below is yours to edit. How this is computed

Per month

$216.11

Per year

$2,593

Per mile

21.6¢/mi

5-year total

$12,965

sedan body style — not this exact model

Notes & official EPA estimate

522.9 gal of fuel / yeargasoline @ $4.96/galAt $5.96/gal: $259.69/mo

A mile road trip costs about $64.80 in energy.

Official FuelEconomy.gov estimate: $3,350/year — assumes 15,000 miles/year and EPA price assumptions. The figures above use your inputs instead.

Compare with another vehiclePrices: EPA national averages, Jul 24, 2026 — override anytime.

At 12,000 miles per year (55% city / 45% highway) with EPA national-average prices ($4.96/gal premium), this 2016 Mercedes-Benz E350 costs about $216.11 per month in fuel — $2,593 per year, 21.6¢/mi, $12,965 over five years.Assumptions are editable below. Prices as of July 24, 2026 · EPA vehicle record #36180. EPA figures are laboratory estimates; real-world cost varies with driving conditions, weather, and where you buy energy.

Mercedes-Benz E-Class: running costs for every model year →

Official EPA efficiency

Measure	Value
City MPG	20
Highway MPG	28
Combined MPG	23

Official EPA estimates

Estimate	Value
Official annual fuel cost (15,000 mi/yr)	$3,350/yr
Tailpipe CO₂	379 g/mi
EPA greenhouse gas score	5/10
EPA smog rating (Bin 5)	5/10

Source: U.S. EPA / DOE FuelEconomy.gov, vehicle record #36180 (record updated 2019-03-13). Snapshot processed 2026-07-26; page data last changed 2019-03-13.

View this record on FuelEconomy.gov

Related configurations

Same year, same family

Adjacent model years