2021 Mercedes-Benz CLS450
3.0L 6-cyl · 9-speed automatic · RWD
HybridPremiumCompact Cars
Official EPA record #43242 from FuelEconomy.gov · data 2026-07-26 · every assumption below is yours to edit. How this is computed
Per month
$193.01
Per year
$2,316
Per mile
19.3¢/mi
5-year total
$11,580
Driving mix55% city / 45% highway
MPG
Your own average replaces the EPA laboratory values — never averaged together with them — and the driving-mix setting stops applying, because a figure you measured already contains your own mix.
Notes & official EPA estimate
467 gal of fuel / yeargasoline @ $4.96/galAt $5.96/gal: $231.92/mo
Official FuelEconomy.gov estimate: $2,950/year — assumes 15,000 miles/year and EPA price assumptions. The figures above use your inputs instead.
Compare with another vehiclePrices: EPA national averages, Jul 24, 2026 — override anytime.
At 12,000 miles per year (55% city / 45% highway) with EPA national-average prices ($4.96/gal premium), this 2021 Mercedes-Benz CLS450 costs about $193.01 per month in fuel — $2,316 per year, 19.3¢/mi, $11,580 over five years.Assumptions are editable below. Prices as of July 24, 2026 · EPA vehicle record #43242. EPA figures are laboratory estimates; real-world cost varies with driving conditions, weather, and where you buy energy.
Official EPA efficiency
| Measure | Value |
|---|---|
| City MPG | 23 |
| Highway MPG | 30 |
| Combined MPG | 26 |
Official EPA estimates
| Estimate | Value |
|---|---|
| Official annual fuel cost (15,000 mi/yr) | $2,950/yr |
| Tailpipe CO₂ | 347 g/mi |
| EPA greenhouse gas score | 5/10 |
| EPA smog rating (Federal Tier 3 Bin 50) | 6/10 |
Source: U.S. EPA / DOE FuelEconomy.gov, vehicle record #43242 (record updated 2021-10-18). Snapshot processed 2026-07-26; page data last changed 2021-10-18.
Related configurations
Same year, same family