2021 Mercedes-Benz E450 4matic

3.0L 6-cyl · 9-speed automatic · 4WD

HybridPremiumMidsize Cars

Official EPA record #43181 from FuelEconomy.gov · data 2026-07-26 · every assumption below is yours to edit. How this is computed

Per month

$193.01

Per year

$2,316

Per mile

19.3¢/mi

5-year total

$11,580

sedan body style — not this exact model

Notes & official EPA estimate

467 gal of fuel / yeargasoline @ $4.96/galAt $5.96/gal: $231.92/mo

A mile road trip costs about $57.90 in energy.

Official FuelEconomy.gov estimate: $2,950/year — assumes 15,000 miles/year and EPA price assumptions. The figures above use your inputs instead.

Compare with another vehiclePrices: EPA national averages, Jul 24, 2026 — override anytime.

At 12,000 miles per year (55% city / 45% highway) with EPA national-average prices ($4.96/gal premium), this 2021 Mercedes-Benz E450 4matic costs about $193.01 per month in fuel — $2,316 per year, 19.3¢/mi, $11,580 over five years.Assumptions are editable below. Prices as of July 24, 2026 · EPA vehicle record #43181. EPA figures are laboratory estimates; real-world cost varies with driving conditions, weather, and where you buy energy.

Mercedes-Benz E-Class: running costs for every model year →

Official EPA efficiency

Measure	Value
City MPG	23
Highway MPG	30
Combined MPG	26

Official EPA estimates

Estimate	Value
Official annual fuel cost (15,000 mi/yr)	$2,950/yr
Tailpipe CO₂	349 g/mi
EPA greenhouse gas score	5/10
EPA smog rating (Federal Tier 3 Bin 50)	6/10

Source: U.S. EPA / DOE FuelEconomy.gov, vehicle record #43181 (record updated 2021-04-26). Snapshot processed 2026-07-26; page data last changed 2021-04-26.

View this record on FuelEconomy.gov — includes owner-shared real-world MPG for this vehicle.

Related configurations

Same year, same family

Adjacent model years