2022 Mercedes-Benz AMG E53 4matic Plus

3.0L 6-cyl · 9-speed automatic · 4WD

HybridPremiumMidsize Cars

Official EPA record #44802 from FuelEconomy.gov · data 2026-07-26 · every assumption below is yours to edit. How this is computed

Per month

$206.87

Per year

$2,482

Per mile

20.7¢/mi

5-year total

$12,410

sedan body style — not this exact model

Notes & official EPA estimate

500.5 gal of fuel / yeargasoline @ $4.96/galAt $5.96/gal: $248.58/mo

A mile road trip costs about $62.10 in energy.

Official FuelEconomy.gov estimate: $3,200/year — assumes 15,000 miles/year and EPA price assumptions. The figures above use your inputs instead.

Compare with another vehiclePrices: EPA national averages, Jul 24, 2026 — override anytime.

At 12,000 miles per year (55% city / 45% highway) with EPA national-average prices ($4.96/gal premium), this 2022 Mercedes-Benz AMG E53 4matic Plus costs about $206.87 per month in fuel — $2,482 per year, 20.7¢/mi, $12,410 over five years.Assumptions are editable below. Prices as of July 24, 2026 · EPA vehicle record #44802. EPA figures are laboratory estimates; real-world cost varies with driving conditions, weather, and where you buy energy.

Mercedes-Benz E-Class: running costs for every model year →

Official EPA efficiency

Measure	Value
City MPG	21
Highway MPG	29
Combined MPG	24

Official EPA estimates

Estimate	Value
Official annual fuel cost (15,000 mi/yr)	$3,200/yr
Tailpipe CO₂	373 g/mi
EPA greenhouse gas score	5/10
EPA smog rating (Federal Tier 3 Bin 50)	6/10

Source: U.S. EPA / DOE FuelEconomy.gov, vehicle record #44802 (record updated 2022-10-13). Snapshot processed 2026-07-26; page data last changed 2022-10-13.

View this record on FuelEconomy.gov

Related configurations

Same year, same family

Adjacent model years