2021 Mercedes-Benz AMG E63 S 4matic Plus (SW)

4.0L 8-cyl · 9-speed automatic · 4WD

GasolinePremiumMidsize Station Wagons

Official EPA record #43541 from FuelEconomy.gov · data 2026-07-26 · every assumption below is yours to edit. How this is computed

Per month

$273.48

Per year

$3,282

Per mile

27.3¢/mi

5-year total

$16,410

station wagon body style — not this exact model

Notes & official EPA estimate

647.3 gal of fuel / yeargasoline @ $5.07/galAt $6.07/gal: $327.42/mo

A mile road trip costs about $81.90 in energy.

Official FuelEconomy.gov estimate: $4,300/year — assumes 15,000 miles/year and EPA price assumptions. The figures above use your inputs instead.

Compare with another vehiclePrices: EPA national averages, Aug 27, 2026 — override anytime.

At 12,000 miles per year (55% city / 45% highway) with EPA national-average prices ($5.07/gal premium), this 2021 Mercedes-Benz AMG E63 S 4matic Plus (SW) costs about $273.48 per month in fuel — $3,282 per year, 27.3¢/mi, $16,410 over five years.Assumptions are editable below. Prices as of August 27, 2026 · EPA vehicle record #43541. EPA figures are laboratory estimates; real-world cost varies with driving conditions, weather, and where you buy energy.

Mercedes-Benz E-Class: running costs for every model year →

Official EPA efficiency

Measure	Value
City MPG	16
Highway MPG	23
Combined MPG	18

Official EPA estimates

Estimate	Value
Official annual fuel cost (15,000 mi/yr)	$4,300/yr
Tailpipe CO₂	483 g/mi
EPA greenhouse gas score	3/10
EPA smog rating (Federal Tier 3 Bin 125)	3/10

Source: U.S. EPA / DOE FuelEconomy.gov, vehicle record #43541 (record updated 2021-09-02). Snapshot processed 2026-07-26; page data last changed 2021-09-02.

View this record on FuelEconomy.gov

Related configurations

Same year, same family

Adjacent model years